At Longboat, our highly specialized pharmacology, 3D animation and medical teams work together to create beautiful bespoke animations highlighting the important details of the disease and investigational drug being trialed in terms of its mechanism of action in the body. These animated videos are something our sponsor’s love, since it can be used in a variety of ways to educate and inform all of the stakeholders taking part in their study. Plus, we get lots of feedback from sites and patients that it’s so much easier to understand how the drug works when it’s explained in a visually engaging way.
So how do the Longboat team bring your protocol to life in 3D and improve site and patient engagement, trial compliance, understanding of complex mechanism of actions inside the body and ensure effective protocol training, even in cases of difficult to explain rare diseases?
1. Review the Disease and Drug Under Study
Thorough review of a range of peer-reviewed sources relating to the disease and clinical drug under study by our team is carried out first to ensure that we fully appreciate all aspects. This includes the minor but not-so-insignificant details and ensuring that we are up-to-date on the latest research. With complete appreciation it becomes simpler to decide what parts are key to include in the animation in order to convey the mechanism of action of the clinical study drug succinctly.
2. Structure Your Animation Simply
At Longboat, we typically structure the video as follows: introduce the disease on a population scale through its epidemiology; narrow down to patient level to highlight symptoms; dive further down into the cellular and sub-cellular level to the molecular pathways involved in the disease; before finally introducing the drug and its mechanism on this scale. This top-down approach helps the animation to flow smoothly and convey the core message.
3. Link the Common Symptoms to the Disease Pathogenesis
Directly linking symptoms to the molecular and cellular aspects of the disease makes the animation more relatable and understandable for the audience as it highlights how symptoms they may observe are influenced by actions on a molecular and cellular level! This also neatly links to how the drug interacts on this molecular and cellular level to potentially alleviate disease symptoms.
4. Focus on the Disease Pathway to Create Context
The method of action of the clinical study drug hinges on the disease pathway it acts on! Therefore, it is important this is explained through the audio and shown on-screen in a concise and stepwise manner, guiding the audience to through the process. Once this is achieved, explaining the mechanism of action of the drug becomes much simpler – since the audience now has an appreciation of the pathway of the disease.
5. Collaborate Across Disciplines
Disease & Drug Overview animation is a collaborative effort involving diverse team members with backgrounds in science and art. We are knitting together complex ideas with beautiful imagery to form an animation that conveys the mechanism of action in a scientifically accurate manner and looks amazing too!
6. Leverage Post-Production Techniques
One final detail that the team at Longboat leverage is the use of post-production techniques. This helps to bring focus to the most important on-screen components and is a simple way to highlight processes such as protein activation or deactivation, or indeed, drug binding. These are microscopic processes, however very important in the grand scheme of the disease development and the drug mechanism of action!
If you want to learn how Longboat can support consistent training and compliance across all stakeholders involved in the success of your clinical trial, we'd love to talk to you.
If you're a talented 3D animation specialist or pharmacologist looking for an opportunity to create leading medical animations, please contact us. We are always looking out for talented people to join the Longboat crew.